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Major progress in our understanding, based on increasingly more precise identification of cell types and intercellular signaling as well as of intracellular molecular cues at play in SSc physio-pathology has spurred enthusiasm in the scientific community and has led to the recent approval of therapeutic agents that may alter the disease course

Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo

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In diabetes mellitus (DM), this balance is disrupted, leading to hyperglycemia, increased blood glucose concentrations [1, 2]