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( k ) An example waveform taken from a single electrode in a MEA well showing detected spike voltage waveforms from the detected local field potentials of overlying cortical neurons

Le X, Puri S, Negrao MV, Nilsson MB, Robichaux J, Boyle T, Hicks JK, Lovinger KL, Roarty E, Rinsurongkawong W, Tang M, Sun H, Elamin Y, Lacerda LC, Lewis J, Roth JA, Swisher SG , Lee JJ, William WN Jr, Glisson BS, Zhang J, Papadimitrakopoulou VA, Gray JE, Heymach JV

This technology has demonstrated the potential to restore FMR1 gene function and improve electrophysiological abnormalities in neurons (219, 220)

For example, the decreased methylation level of the BCAT1 promoter in HCC tissues leads to increased BCAT1 expression, over activating the AKT signaling pathway and promoting epithelial-to-mesenchymal transition (EMT), thereby facilitating the occurrence and metastasis of liver cancer cells (78, 79)

When urine was analyzed, less than 5% of the administered -alanine was detected