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However, the study was limited by its small sample size, open-label design, and inclusion of concomitant psychotropic medications, which makes it difficult to draw firm conclusions about efficacy

Of the other sites we propose, some are more likely than others, but those in TXNRD1 and SELENOF are particularly convincing, and all of the predicted sites map to surface accessible regions of the targeted proteins (Figure S3)

Perhaps more enlightening with respect to GSNOs role in physiology are similar comparisons in mice with knock out of the primary GSNO metabolizing enzyme, GSNO reductase (also known as GSNOR)

The efficiency of expression may be enhanced by the inclusion of appropriate transcription enhancer elements, transcription terminators, etc

112 (2): e1325