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Oxidative stress occurs when the body has too many unstable molecules called pro-oxidants free radicals and reactive oxygen species (ROS)

However, the specific antioxidative metabolites produced by metformin-treated microbiota and their anti-IIRI effects have not been fully elucidated

Antioxidant status and lipid peroxidation in colorectal cancer

The failure of the antioxidant system to negate the pathological rise in the oxidative species is exacerbated by reduction in levels of the major cellular nucleophile, GSH due to their covalent modification by dopamine quinone species 20,43,44,45

Interestingly, stabilization of O-GlcNAcylation increased the number of Ezh2 and Ezh2/OGT target genes and EZH2 O-GlcNAcylation plays a role in EZH2 recruitment to the promoter of defined HCC-relevant direct target genes