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Graphical Abstract 1 Introduction Amyotrophic lateral sclerosis (ALS) is a fatal disorder characterized by the selective degeneration of upper motor neurons in the primary motor cortex and lower motor neurons in the brainstem and spinal cord, leading to progressive muscle weakness and atrophy (Masrori and Van Damme, 2020)

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Impact of treatment end point definitions on perceived differences in long-term outcome with tyrosine kinase inhibitor therapy in chronic myeloid leukemia

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