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Intranasal delivery using a lung-tropic adeno-associated virus 9 vector to prime and chemokine pull (CXCL11) effectively induced SARS-CoV-2-specific lung-resident T cells and offered better protection against SARS-CoV-2 in mice [168] (Table 2)

Accumulating evidence indicates that gut and other mucosal-associated microbiota are closely related to, and potentially participate in, the development of various chronic inflammatory and autoimmune diseases (e.g., rheumatoid arthritis, Hashimotos thyroiditis) via pathways such as immune regulation and metabolic remodeling mediated by microbial metabolites (167170)

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An RDP crossover study found that the endurance time of a group of recreational athletes was significantly increased after Pycnogenol supplementation (53)

Oral glutamine protects against acute doxorubicin-induced cardiotoxicity of tumor-bearing rats