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All other data supporting the findings of this study are available from the corresponding authors on reasonable request

In our previous study, pharmacokinetic and pharmacodynamic analyses ( n = 145) demonstrated that L-serine exhibited greater efficacy at higher doses, with regimens equivalent to 400 mg/kg/day leading to notable increases in K-VABS-II-ABC scores (1.73.7 points vs

3b), suggesting that the TLS factors responsible for SBS-PolkKO mutations are not preferentially associated with either the lagging or leading strands

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