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Generation of new viral RNAs requires several key enzymatic subunits within the replicase, including an RNA-dependent RNA polymerase (RdRp) that builds RNA strands with ribonucleotides [1, 10]

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Gehlert D.R

Hao C, Wang L, Peng S, Cao M, Li H, Hu J, Huang X, Liu W, Zhang H, Wu S, Pataer A, Heymach JV, Eterovic AK, Zhang Q, Shaw KR, Chen K, Futreal A, Wang M, Hofstetter W, Mehran R, Rice D, Roth JA, Sepesi B, Swisher SG , Vaporciyan A, Walsh GL, Johnson FM, Fang B

Thus, this is the first study to identify Pellino3 as an E3 ubiquitin ligase targeting GSK3 in hepatocytes and reveal its pathophysiological role in Peli3 / KO mice orally administered APAP