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Foteinou PT, Venkataraman A, Francey LJ, Anafi RC, Hogenesch JB, Doyle FJ 3rd (2018) Computational and experimental insights into the circadian effects of SIRT1

By binding to actin monomers (individual actin molecules), TB-500 controls their availability for polymerization into filaments

1 While traditionally studied in isolation, recent advances reveal extensive crosstalk between these pathways, which coordinate protein turnover, stress responses, and quality control under physiological and pathological conditions