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LScalisiNMBelfioreAVigneriRet al

This fibrotic transition, often associated to aging (183), obesity (184) and diabetes (185), markedly impairs cardiac function through multiple mechanisms (182)

Route, concentration, formulation, copper coordination and tissue exposure are materially different

Toxicol ., 8: 46-51

Among these, ionizable lipids have been proposed to elicit endosomal rupture 17 , leading to activation of the NOD-like receptor protein 3 (NLRP3) inflammasome 18