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For example, in hereditary leiomyomatosis and renal cell cancer (HLRCC), a high level of fumarate caused by genetic mutation of fumarate hydratase induces the succination of Kelch-like ECH-associated protein 1 (KEAP1) accompanied by the consumption of a fumarate molecule 134,135

Figure 1 TMAO and Inflammation-Immunity AS is a chronic inflammatory disease in which the innate and adaptive immune systems respond to many endogenous and exogenous molecules and highly diverse challenges (Ross, 1999

[DOI] [PubMed] [Google Scholar] 2.Thomas LW, Ashcroft M

Ostrakhovitch EA, Tabibzadeh S

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