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IDD can lead to many related and often progressive medical conditions as a result of spinal instability, disc herniation, and nerve impingement such as spondylosis, which refers to degenerative and osteoarthritic changes to the discs and vertebral bones, and sciatica, where pressure put on the sciatic nerve root by a herniated disc or bone spur can cause discomfort, pain, and limb weakness (Mulleman et al., 2006

Curr Opin Pharmacol 6(4):379386 Ip WKE et al (2017) Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

Some of the major pathways include excision repair (nucleotide excision repair [NER] and base excision repair [BER]) and recombinational (or double-strand break) repair (DSBR) [183]