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doi: 10.1084/jem.177.2.547

135 Zhou DW, Wu LJ Effect of compound Centella asiatica tablets combined with western medicine on expression of ER, PR and Ki-67 of patients with galactophore lobule hyperplasia

One-carbon metabolism requires B vitamins, and hence the efficient dietary supply may protect against cancer by reducing DNA instability and by affecting DNA methylation [42], but vitamin B12, methylcobalamin, and coenzyme B12 were found to enhance DNA methylation in the presence of S-adenosylmethionine for concentrations up to 1 M, but at higher concentrations, these compounds were found to inhibit DNA methylation [43]