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[29]Current Patent Assignee: NITROMED - US5994294, 1999, A

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Brain Res 1214:177187 Lv L, Yang F, Li H, Yuan J (2020) Brain-targeted co-delivery of -amyloid converting enzyme 1 shRNA and epigallocatechin-3-gallate by multifunctional nanocarriers for Alzheimers disease treatment

In multiple oxidative stress models of retinal degeneration, elevated GPX4 expression has been shown to protect photoreceptors and RPECs, suggesting that increasing GPX4 expression may represent a potential gene therapy approach for patients with AMD (47, 48)