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Their low bioavailability, short half-life in the body, and complex metabolic conversion make it difficult to achieve effective therapeutic concentrations ( in vivo even when concentrations are extremely low, facilitating a more precise evaluation of their bioavailability ( Current reviews mainly focus on the impacts of particular subclasses of flavonoids or their effects within particular disease contexts, while a holistic perspective is absent

Cellular metabolites and drug byproducts often complicate chemotherapy efficacy with poorly defined molecular mechanisms 20,21,22,23

Out of all genomic regions, long read sequencing provides advantages in studying repetitive elements, which are difficult to characterize through other sequencing methods

Chem Sci 8:33903398

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