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Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity

The CAG140 knock-in (KI) mouse model exhibits abnormal mHTT aggregates, striatal transcriptional deficits, and early-onset motor, cognitive and affective impairments

In fact, TMAO has been found in cerebrospinal fluid (CSF) of individuals with neurological disorders at concentrations 0.116.43 mol/L (Vogt et al., 2018)

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Studies have shown that an increased level of homocysteine in the blood may be an independent risk factor for cardiovascular disease, as it can contribute to damage to the vascular wall and promote blood clots [8, 9]