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Chen found in human melanoma cells that silencing iPLA2 would enhance the sensitivity to p53-mediated ferroptosis without significant effects on cells that usually express iPLA2, suggesting that iPLA2 can inhibit p53-mediated ferroptosis, and p53-driven ferroptosis is independent of GPX4 [41]

Pulsatile Secretion The natural pattern of growth hormone release, which occurs in bursts or waves rather than a steady stream

The nerve stimulation parameters used were 1 Hz pulse and 3 mA current

The observed reduction in mammary stem cell (MaSC) activity and self-renewal capacity of luminal progenitors underscores sirolimus potential to directly impede the cellular origins and maintenance of breast cancer

Kimatu et al