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Such fluctuations play a vital role in maintaining the 24-hour rhythm of the cells

doi:10.1038/nrc2012 57

tau, amyloid, and prion, -synucleino-pathy are deregulated signaling mechanism(s) that synchronize to affect neuronal damage

Azimian H, Bahreyni-Toossi MT, Rezaei AR, Rafatpanah H, Hamzehloei T, Fardid R (2015) Up-regulation of Bcl-2 expression in cultured human lymphocytes after exposure to low doses of gamma radiation

The increased oxidative load disrupts the bodys intrinsic antioxidant defense systems, such as manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx), leading to lipid peroxidation, DNA damage, and activation of pro-apoptotic pathways, such as p53 and BAX 5,7