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All the remaining authors declared no conflicts of interest or personal relationships that could have influenced the work presented in this article

Microb Pathogenesis 148

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Key Benefits: Smooths the look of stubborn deep lines, wrinkles & creases Targets visible expression lines, including marionette, lip, frown & nasolabial folds (smile lines) Helps wrinkle depth appear shallower over time Featured Ingredients: Neuropeptides: Protein-like messenger molecules reduce the look of stubborn expression lines and deep creases by supporting visible skin renewal for a relaxed, smooth appearance

These differences indicate an adaptation in the threshold for induction of cold thermogenesis by peripheral vasoconstriction [56,63,64]