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Description

(the enzyme that actually uses glutathione to neutralize free radicals)

Glutathione regulates the expression of gamma-glutamylcysteine synthetase via the Met4 transcription factor

10.1007/s13273-021-00171-4 123 KimS

Within the intricate control of GPX4, M1 and M2 macrophages show contrasting vulnerability to ferroptosis triggered by GPX4 inhibitors (Kapralov et al., 2020)