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To separate a phenotype caused by Gpx4 -deficiency from that of Cre side effects, tamoxifen-treated mice harboring Gpx4 fl/fl ;Cre ERT2 and Gpx4 wt/wt ;Cre ERT2 BM cells were allowed to recover and blood was drawn every three weeks (Figure 1)

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Quantitative metabolite profiling typically comes after qualitative profiling because the understanding of how much is often as important as what is it, especially as the drug makes its way along the discovery and development path

Although red cell survival remains shortened as long as use of the drug continues, compensation by the erythroid marrow effectively abolishes the anemia in subjects with G6PD A (Fig