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LDN has the ability to reduce pro-inflammatory cytokines as it was found to be allied with a decline of plasma concentrations of transforming growth factor (TGF)- which belongs to a group of cytokines that is together called The super-family TGF-, and also responsible for regulating epithelial cell differentiation, expansion , organization, motility, and apoptosis [98]

Regretfully, standardized and reliable biomarkers for evaluating oxidative or RS in infertile men are currently lacking [60]

The term scatter factor was later introduced independently in 1985 by Stoker and co-workers, as they discovered a protein interrupting the intracellular junctions of epithelial cells thereby promoting their migration in a paracrine manner and promoting an invasive phenotype [4]

For 13 C-labeled metabolites, we retrieved their metabolic reaction relationship from metabolic reaction network curated using the KEGG database, which results in reaction pairs (RPs) between labeled metabolites (Fig

Hammarstedt C