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Conclusions The results from this study showed that blood GSSG, MDA, homocysteine, SAH, nitric oxide, and copper concentrations were significantly increased, whereas GSH, tGSH, GSH/GSSG, tGSH/GSSG, SAM/SAH, methionine, cysteine, vitamins (B9, B12, D, and E), and calcium concentrations were significantly reduced in children with ASD

Stress, pollution, and a poor diet pull it down further

B.VerheijM.Haimovitz-FriedmanA

It downregulates nNOS mRNA expression confirmed by real-time polymerase chain reaction (RT-PCR)

In the nucleus, Nrf2 interacts with small Maf proteins (sMAF) and binds to antioxidant response elements (ARE), promoting the transcription of downstream antioxidant genes (Yan et al., 2023)