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Researchers synthesized the four-amino acid sequence Ala-Glu-Asp-Gly to create a stable, reproducible research compound that could be studied without relying on biological extracts

As anticipated, MS analysis showed co-fractionation of Flag-Strep ASXL1 with other subunits of the PR-DUB BAP1 complex, including BAP1, HCF-1 and FOXK1/2, as well as MLL3 from MLL3/4 complexes (Fig