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Often, a combination approach works best

De Palma, M., Biziato, D

Unlike the well-studied CagriSema combination (cagrilintide + semaglutide) with proven 15-25% weight loss results from Phase 3 trials, adding cagrilintide to tirzepatide remains completely unstudied

They are not a replacement for emergency care, crisis support, or treatment for severe psychiatric conditions, but they can be considered as an adjunct when someone is medically stable and looking for more complete brain and mood support