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Symptoms of vitamin B12 deficiency include (1): chronic fatigue shortness of breath heart palpitations tingling or numbness in the extremities poor balance loss of concentration poor memory disorientation mood changes incontinence insomnia People most at risk of developing a deficiency include older adults, as well as those who smoke, abuse alcohol, or follow a vegetarian or vegan diet

Alpha-fetoprotein (AFP) is a glycoprotein that is highly expressed in embryonic liver and in hepatic progenitor cells (hepatoblasts) ( in vitro cultured hepatocytes obtain and maintain a mature differentiated state versus a proliferative dedifferentiated phenotype

Neoangiogenesis and Immune-regulation are Two Fundamental Functions of VEGF VEGF-induced neoangiogenesis is the determining factor of cancer progression As the primary mediator of tumor-angiogenesis, VEGF plays a significant role in tumor growth

Chen L-Y, Kang Y-N, Hoang KD, Chen K-H, Chen C

Mukaremera and Nielsen, 2017)