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There is a growing recognition for the need for a common therapeutic regimen to target organ crosstalk to treat this cardiorenal feedback

Arsenic, cadmium, mercury and nickel stimulate cell growth via NADPH oxidase activation

Sdal et al., 2023

The reduction of human RNR, which was suggested to follow mechanism (ii) 46 , therefore needs to be analyzed and monothiol mechanism (iii) should be also considered