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Chemopreventive and therapeutic effects of curcumin

Kennedy et al, 2014

However, when mitochondria are depolarized or damaged, PINK1 accumulates in large quantities in the OMM, translocating Parkin from the cytoplasm to the OMM by up-regulating its autophosphorylation and phosphorylating Parkin (ubiquitin, Ub) via its C-terminal kinase region [27]

The Wnt--catenin pathway is pivotal for intestinal cell specification, enabling Wnt proteins, mostly secreted by mesenchymal and Paneth cells, to trigger signaling in neighboring cells 17