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Description

Many of these placebo-controlled studies have demonstrated that folic acid supplementation improved symptoms in severely depressed patients, elderly depressed and demented patients, and those with major acute depression or schizophrenia, particularly in individuals with RBC folate levels below 453 nmol/L (46)

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Most cases are identified through blood tests ordered for other reasons, such as investigating anaemia, fatigue, or monitoring patients with known liver or kidney disease