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Trends Cell Biol (2019) 29:48799

Improper stimulation of microglial cells is a pathogenic marker in several neurodegenerative disorders, such as Parkinsons (Gao et al., 2023)

Functionally, brain activation patterns reorganize, characterized by reduced lateralization (e.g., increased bilateral prefrontal cortex activation during memory retrieval) and compensatory increases in prefrontal cortex activity coupled with decreased activity in posterior brain regions