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In healthy rats, it increased insulin levels by more than 500%, exerting a marked hypoglycemic effect throughout the experiment, while glucose levels returned to baseline despite only increasing insulin by just under 25% in hyperglycemic rats

MG-induced DNA damage plays a central role in initiating apoptosis.MG induces DNA strand breaks through the formation of adducts (e.g., MGdG) and cross-linking structures with DNA, activating the intracellular DNA damage response, and triggering apoptosis by cell cycle arrest when the damage exceeds the cellular ability to repair it (104)

The Lancet Respiratory Medicine (2020)

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