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Thus, organoids have provided insights into the complex pathophysiology of MELAS, indicating that neurodevelopmental defects are intrinsic to MELAS

EV engineering strategies: targeted modification and gene editing

Consequently, Epigenetic modifications, encompassing DNA methylation, histone alterations, and non-coding RNA interactions, intricately regulate gene expression, playing a pivotal role in HPV-induced carcinogenesis by modulating oncogene expression, DNA repair processes, and immune evasion strategies