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10.1016/j.atherosclerosis.2021.05.020 157

Challenges of Ferroptosis in GIME The glioma immunosuppressive microenvironment (GIME) is the main reason for poor efficacy of immunotherapy in glioma (93, 94)

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The local inflammatory microenvironment in the ovary, characterized by elevated levels of pro-inflammatory cytokines such as IL-18 and IL-1, impairs the function of follicular granulosa cells and accelerates follicular atresia, ultimately contributing to polycystic-like morphological changes in the ovary (62)