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monocytogenes has a counter-intuitive effect on the antioxidant capacity and pathogenicity

N Engl J Med 367:10871097

In this study, scientists found that activation of cGAS-STING signaling increased the levels of mitochondrial reactive oxygen species, which induced the phosphorylation of mammalian sterile 20-like kinase 1 and then activated forkhead box1, subsequently promoting FLS migration and invasion (64)

This state promotes neutrophil-mediated inflammatory infiltration, enhances protease secretion, and elevates the generation of oxidative intermediates