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Furthermore, technologies such as microfluidics or flash nanoprecipitation should be explored as they offer greater control over nanoparticle size and composition to ensure consistent biological response and GMP compliance 145,148,149

PMID 17454552

The limits of passive targeting techniques are highlighted by thorough assessments of nanoparticle delivery efficiency, which have revealed that, on average, less than 1% of the injected nanoparticle dosage penetrates solid tumors [11, 12]

But the mechanism here is plausible enough to warrant attention in human studies too

Further synthetic strategies should consider incorporating substituents to increase the degree of nucleophilic attack at the sulfur in selenenyl sulfide