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Preserve methyl donors (SAM) less NNMT activity means a better SAM:SAH balance, which can steady epigenetic gene regulation

For these people, taking more and more vitamin B12 isnt going to solve their problem

Some people do well on lipotropic and B12 shots alone

The predicted inhibitor-binding mode of 1j with an orientation and conformation that favors most negative docking score when superimposed with the endogenous substrate NCA of the NNMT enzyme indicated that the analog binds consistent with the binding mode of NCA, i.e., the N1-atom of both ligands aligned almost identical, conferring similar molecular interactions with key residues within the active site of the enzyme

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