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On the other hand, TMAO decreases expression of two key enzymes, CYP7A1 and CYP27A1, essential for bile acid biosynthesis and multiple bile acid transporters (OATP1, OATP4, MRP2 and NTCP) in the liver, which decreases bile acid pool, resulting in decreased reverse cholesterol efflux (Koeth et al., 2013)

Our high-strength quick-release softgels deliver 2,500 mg per serving, offering a potent dose of this

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This reversibility and the fact that the reaction does plateau and approach equilibrium will be taken into account within the kinetic model by including maxima and minima in the functions (see below)