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Compounding pharmacies prepare micronized progesterone in capsules, topical creams, vaginal inserts, and sublingual troches at custom dosestypically 25 mg to 400 mgallowing prescribers to match the dose to the clinical scenario rather than the pharmacy shelf

PT, a methoxylated analog of resveratrol, exhibits pleiotropic pharmacological activities including anti-cancer, neuroprotective, anti-obesity, anti-diabetic and anxiolytic activities ( Compared with retinoids, PT displays equivalent procollagen I restoration yet superior suppression of mitochondrial ROS without provoking erythema, desquamation, or photosensitivity ( Malfunctioning mitochondria can lead to a wide range of cellular problems, including increased oxidative stress and impaired energy metabolism ( Mitochondrial dynamics, biogenesis, and mitophagy are crucial processes that coordinate to maintain mitochondrial homeostasis and restore damaged mitochondrial function ( Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding authors

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