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Neuropathological studies have provided evidence of reduced GABAR levels in the cortex and hippocampus, aberrant GAD1 and GAD2 mRNA expression in the postmortem cortex and cerebellum, and the interneuron markers parvalbumin (PV) and somatostatin (SST) are downregulated

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[DOI] [PubMed] [Google Scholar] Tkalcevi VI, Cuzi S, Brajsa K, et al

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Can be given in muscle or fat for easier self-administration