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Moreover, the combination treatment significantly reduces glucose absorption and lactate production, countering the Warburg effect and impeding the glycolytic shift associated with the Warburg effect

Similar to these studies, there are studies in which vitamin C (Reference Savran, Cicek and Doguc7) , resveratrol (Reference zgmen and Yeilot44) , quercetin (Reference Yuksel, Yuksel and Yagmurca45) , berberine (Reference Mehrzadi, Fatemi and Esmaeilizadeh48) and gallic acid (Reference Olayinka, Ore and Adeyemo43) were used to treat MTX-induced tissue damage

However, trials are ongoing and conclusive results are not expected before June 2012

doi: 10.1016/j.bbagen.2017.05.019 41 LuoLLiuKDengLWangWLaiTLiXet al