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Although the study did not meet its primary endpoint (placebo-corrected change in the overall mFARS score at 72 weeks), vatiquinone treatment demonstrated nominally significant and clinically meaningful benefits in specific disease subscales, most notably preserving upright stability and reducing fatigue, with an excellent safety profile

Increasing glutathione levels has shown to improve vascular health, muscle strength, bone density, inflammation, immunity, cognitive function as well as delaying neurodegeneration

Second, existing biomarkers have not been adjusted for age differences between pediatric and adult TBI patients, leading to high false-positive rates for children in multicenter cohorts

Unfortunately, the number of subjects included in this study was only six