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Modest orthostatic decreases in blood pressure and modest tachycardia were each seen in approximately 20% of patients taking clomipramine hydrochloride capsules in clinical trials

Kanemura T, Tamaoki J, Horii S, Sakai N, Kobayashi K, Isono K, Takeuchi S, Takizawa T

A reduced redox state is essential for CSC self-renewal and, therefore, CCA CSCs were shown to rely on powerful antioxidant networks to detoxify mitochondrial reactive oxygen species and maintain stemness in oxidative CSCs

BMD modeling The in vitro comet assay datasets with positive outcomes were analyzed by fitting concentrationresponse models using BMD modeling and then ranking the different NAs regarding their relative in vitro comet assay response in the different liver cell models