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In addition to histones, deubiquitinating enzymes regulate autophagy by stabilizing nonhistone components of the autophagy machinery

Brain Res 872(12):258261

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Rishniw and Brown warn that such breeds as the CKCS "likely require breed-specific reference intervals for LVIDDN to correctly identify left ventricular enlargement." They also point out: "For example, if a dog has a LVIDDN that consistently oscillates around 1.3 (within 0.1 units), an increase to 1.6 could indicate left ventricular enlargement for that dog, despite being within the population-based reference interval." Well, in the EPIC Study, due to the lack of any inclusion criteria relevant to heart enlargement, the peers have every reason to justifiably doubt its results