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Mutant HTT directly attacks the mitochondrial membrane and alters calcium homeostasis (Suzuki et al., 2012), and induces mitochondrial dysfunction by damaging mitochondrial DNA (Yang et al., 2008) mitochondrial fission/fusion mechanisms, and mitochondrial energy metabolism (Song et al., 2011)

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This happens because a deficiency in vitamin B12 leads to reduced oxygen supply in your body due to fewer red blood cells

Currently, intravenous NAD+ infusion is the only recognized method for reliably increasing NAD+ levels[10]