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Concerning the hypertension mechanisms, the oxidative stress was shown in the rostral ventrolateral medulla (RVLM) [10] and in kidney [11] and are both present in spontaneously hypertensive rats (SHR)

Estrogens regulate calcium metabolism, intestinal calcium absorption, and parathyroid gene expression and secretion, triggering fluctuations across the menstrual cycle

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Its modulation of key pathways like PI3K/AKT and NF-B disrupts tumor growth and metastasis, underscoring its potential as an adjunct to conventional therapies