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demonstrated that treating Caco-2 cells (which structurally and functionally resemble differentiated small intestinal epithelial cells) with coffee bean extract(CBE)-treated fecal microbiota suppressed MRP4 expression, whereas CBE alone did not have this effect

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12 Meanwhile, computational design approaches are accelerating the development of PROTACs and AUTACs, enabling targeted degradation of disease-associated proteins through UPS or autophagy, respectively

Gunderstoftes study demonstrated that genetic activation of Nrf2 increased the infectiability and the replication of HSV-2 in Keap1 (/) mouse embryonic fibroblasts (Gunderstofte et al., 2019)