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Specifically, sirtuins participate in multiple physiological reactions that regulate cellular metabolism through the NAD + -dependent deacetylation of target proteins including histones, such as H1, H3 and H4, transcription factors and co-activators, including p53, NF-B, peroxisome proliferator-activated receptor- co-activator-1 (PGC-1) and forkhead box O1 (FOXO1), and signalling regulators of metabolism, including protein kinase A, 5-AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR) [37,38,39,40,41,42,43]

Jacoby, D

RNA/protein complexes and organelles, such as the mitochondria, are synthesized in the soma and transported along the axon

Impact of endogenous nitric oxide on microglial cell energy metabolism and labile iron pool

- Intgr Med (Encinitas)