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IV therapy with antioxidants is not an established treatment for RA or gout flares

Unlike acute inflammation, which serves to eliminate pathogens and initiate healing, chronic inflammation fails to resolve and consequently creates a microenvironment conducive to disease progression, including cancer development [128]

Some other drug options include: Corticosteroids: Local steroid injections can provide pain relief Tumor necrosis factor (TNF) inhibitors: Other biologic treatments: secukinumab (Cosentyx) Oral small molecules: tofacitinib (Xeljanz) AS can affect the whole body, and a person physical therapists eye specialists cardiologists neurologists gastroenterologists A common complication of AS is inflammation of the eyes, causing pain and redness

The consequence of this interaction is the breakdown of immune tolerance, manifested by the proliferation of follicular helper T (Tfh) and Th17 cells, impaired function of Tregs, aberrant B-cell activation leading to excessive autoantibody production, elevated levels of inflammatory mediators, multiorgan inflammation, and tissue damage, ultimately culminating in the development of autoimmune disorders

Arredondo, M., Muoz, P., Mura, C