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The pharmaceutical composition of claims 73 , wherein said second agent is 3,3-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one

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This deleterious process is initiated by the activation of CNS-resident microglia, which release an array of cytokines and chemokines, including C-C motif chemokine ligand 2 (CCL2) and C-X-C motif chemokine ligand 10 (CXCL10), that not only amplify local inflammatory responses but, more critically, alter BBB permeability through disruption of tight junction integrity (53, 54)

Abstract Introduction Intramedullary melanocytomas are rare central nervous system tumors originating from melanocytes within the spinal cord