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Development to adult stage was assessed 4 days later and representative images are shown in panels (A-L)

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For seasonal allergies, some researchers begin KPV protocols 2 to 4 weeks before allergy season starts, aiming to stabilize mast cells before peak pollen exposure

144 A more recent meta-analysis by Yang et al examined metformin use and neuropathy and found no association, highlighting similar issues in terms of the lack of randomised controlled trials, small sample size and varying study design as described above